Tumor-induced neutrophil extracellular traps-drivers of systemic inflammation and vascular dysfunction
Jessica Cedervall1, Anna Dimberg2, Anna-Karin Olsson1
1Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Biomedical Center , Uppsala, Sweden.
Abstract:
Neutrophil extracellular traps (NETs) are part of the innate immune defense against microbes, but their contribution to several non-infectious inflammatory conditions has recently been unraveled. We demonstrate that NETs accumulate in the peripheral circulation in tumor-bearing mice, causing systemic inflammation and vascular dysfuntion in organs not affected by tumor cells.
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