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Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice

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Procarcinogenic regulatory T cells in microbial-induced colon cancer

Abby L Geis¹, Franck Housseau¹

¹Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University , Baltimore, MD, USA.

|May 4, 2016

Abstract:

Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

Keywords:

Carcinogenesis; Enterotoxigenic Bacteroides fragilis; IL-17; inflammation; Microbiome

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