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Related Experiment Videos

Rectal sensitivity in chronic constipation.

A De Medici1, D Badiali, E Corazziari

  • 1Cattedra di Gastroenterologia I, Universitá di Roma La Sapienza, Italy.

Digestive Diseases and Sciences
|May 1, 1989
PubMed
Summary
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Reduced rectal sensitivity is common in chronic constipation, particularly with prolonged gastrointestinal transit time and rectal slow transit. Sensitivity improved with treatment in responders, indicating a potential therapeutic target.

Area of Science:

  • Gastroenterology
  • Neurogastroenterology
  • Colorectal Disorders

Background:

  • Chronic constipation is frequently associated with altered rectal sensitivity.
  • The relationship between rectal sensitivity, gastrointestinal transit time, and the location of transit abnormalities remains unclear.
  • It is unknown whether altered rectal sensitivity precedes or follows the onset of constipation symptoms.

Purpose of the Study:

  • To investigate rectal sensitivity in patients with chronic constipation.
  • To determine if rectal sensitivity differs based on the severity and site of gastrointestinal transit slowing.
  • To assess if rectal sensitivity changes occur before or after treatment.

Main Methods:

  • Evaluated perception of intrarectal distension in healthy controls and constipated patients with normal or prolonged gastrointestinal transit times.

Related Experiment Videos

  • Analyzed rectal sensitivity based on the location of transit slowing (rectum only, colon only, or both).
  • Assessed changes in rectal sensitivity before and after treatment in a subgroup of patients.

    • Main Results:

    • Rectal sensitivity was significantly reduced in constipated patients compared to controls.
    • Patients with prolonged gastrointestinal transit time and rectal slow transit exhibited more severe reductions in rectal sensitivity.
    • Rectal sensitivity improved in patients who responded to treatment, but not in non-responders.

    Conclusions:

    • Reduced rectal sensitivity is a significant finding in chronic constipation, especially with delayed colonic and rectal transit.
    • Rectal sensitivity appears to be linked to the severity and location of gastrointestinal transit abnormalities.
    • Improvement in rectal sensitivity correlates with treatment response, suggesting its role in the pathophysiology and management of constipation.