Related Experiment Video

Updated: Mar 21, 2026

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

20.6K

[EARLY ENTEROVIRUS NEONATAL INFECTION: WHEN SHOULD WE THINK ABOUT IT?]

D Lagae, V Rigo, J-M Senterre

    Revue Medicale De Liege
    |May 5, 2016
    PubMed

    Insights

    Early detection of enterovirus (EV) infections in newborns using Real-Time Polymerase Chain Reaction (RT-PCR) is crucial. Prompt EV testing can reduce antibiotic use and hospital stays for neonatal meningitis.

    Area of Science:

    • Neonatal infectious diseases
    • Virology
    • Clinical microbiology

    Background:

    • Enterovirus (EV) infections can lead to severe neonatal syndromes, including sepsis-like presentations.
    • Current diagnostic algorithms for neonatal infections often overlook timely viral testing.
    • EVs are associated with significant neonatal morbidity and mortality rates.

    Observation:

    • Three cases of enterovirus meningitis were identified in neonates within the first week of life.
    • Affected infants presented with fever and irritability.
    • Enterovirus infection was confirmed via Real-Time Polymerase Chain Reaction (RT-PCR) on cerebrospinal fluid (CSF), with blood RT-PCR positive in two cases.

    Findings:

    • All three neonates recovered without adverse outcomes and were discharged shortly after.
    • Early identification of EV infections is critical for appropriate management.
    • RT-PCR testing on blood and CSF can facilitate rapid diagnosis.

    Implications:

    • Implementing early EV RT-PCR testing in blood and CSF can improve neonatal outcomes.
    • Timely diagnosis may reduce unnecessary antibiotic administration.
    • Early detection can potentially shorten the duration of hospitalization for affected newborns.

    More Related Videos

    A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

    A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

    Published on: August 12, 2020

    7.0K
    In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis09:11

    In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis

    Published on: June 8, 2022

    2.9K

    Related Concept Videos

    Viral Meningitis01:18

    Viral Meningitis

    Viral meningitis is the most common form of meningitis and is often referred to as aseptic meningitis to indicate the absence of bacterial involvement. It is generally milder than bacterial meningitis, with symptoms including fever, headache, stiff neck, drowsiness, nausea, photophobia, and vomiting. Rarely, more severe manifestations or death may occur. Common causative agents include enteroviruses, particularly coxsackie A and B viruses and echoviruses, all members of the Enterovirus genus...
    8
    Cytomegalovirus Disease01:27

    Cytomegalovirus Disease

    Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
    7
    Bacterial Gastroenteritis01:18

    Bacterial Gastroenteritis

    Bacterial gastroenteritis, characterized by diarrhea, abdominal cramps, and vomiting, is often caused by ingestion of contaminated food or water and is frequently associated with pathogenic Escherichia coli strains. These microbes exploit two principal mechanisms to inflict disease.Shiga toxin–producing E. coli, also referred to as STEC—notably O157:H7—release Shiga toxins that target ribosomes, blocking protein synthesis. The B subunit of the toxin binds the host glycolipid...
    10
    Arboviral Encephalitis01:25

    Arboviral Encephalitis

    Arboviral encephalitis refers to brain inflammation caused by arthropod-borne viruses, particularly those transmitted through mosquito vectors. Among these, West Nile virus (WNV), a member of the Flaviviridae family, is a significant public health concern. WNV is an enveloped, positive-sense, single-stranded RNA virus. Human infection typically begins when an infected mosquito introduces the virus into the dermis during feeding. The primary transmission cycle involves birds as amplifying hosts...
    3