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Advances in pharmacovigilance initiatives surrounding antimicrobial resistance-Indian perspective

Laxminarayana Kurady Bairy1, Veena Nayak1, Avinash A1

  • 1a Department of Pharmacology , Kasturba Medical College, Manipal University , Manipal , India.

Expert Opinion on Drug Safety
|May 5, 2016
PubMed
Abstract

Insights

Antimicrobial resistance (AMR) is accelerating, with new drug discovery slowing. This review examines AMR mechanisms, consequences, and pharmacovigilance, highlighting the need for global surveillance and action plans to combat this growing threat.

Area of Science:

  • Microbiology
  • Pharmacology
  • Public Health

Background:

  • The accelerating development of antimicrobial resistance (AMR) is a significant global health concern.
  • The discovery of new antimicrobial agents has markedly slowed in recent decades, exacerbating the AMR crisis.

Purpose of the Study:

  • To review the multifaceted problem of antimicrobial resistance (AMR).
  • To explore the various mechanisms contributing to AMR, its consequences, and future outlook.
  • To highlight irrational antimicrobial use, strategies for improving antimicrobial stewardship, and pharmacovigilance challenges related to AMR.

Main Methods:

  • This study is a comprehensive review of existing literature on antimicrobial resistance.
  • It synthesizes information on AMR mechanisms, consequences, and future trends.
  • The review also focuses on antimicrobial usage patterns and pharmacovigilance issues.

Main Results:

  • Antimicrobial resistance (AMR) poses a substantial threat due to accelerating resistance and slowed drug discovery.
  • Irrational antimicrobial use and inadequate pharmacovigilance contribute to the AMR problem.
  • Global surveillance of antibiotic use, like the WHO's WHONET program, is ongoing but lacks complete geographical representation.

Conclusions:

  • Effective pharmacovigilance and global surveillance are crucial for combating antimicrobial resistance (AMR).
  • Expanding data collection worldwide is essential for a comprehensive understanding of AMR.
  • Successful implementation of the WHO's global action plan is vital for reducing AMR and evaluating interventions.
Keywords:
Antimicrobial resistanceWorld Health Organizationinfectious diseasespharmacovigilance

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