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Degenerative Mitral Stenosis: Unmet Need for Percutaneous Interventions
Karan Sud1, Shikhar Agarwal1, Akhil Parashar1
1From Departments of Cardiovascular Medicine (K.S., S.A., M.Q.R., K.P., D.M., L.L.R., A.K., E.M.T., S.R.K.), Internal Medicine (A.P.), and Thoracic and Cardiovascular Surgery (S.L.M., A.M.G.), Cleveland Clinic, OH.
Circulation
|May 5, 2016
Summary
Degenerative mitral stenosis (DMS), caused by mitral annular calcification, affects elderly patients. New percutaneous treatments are needed for high-risk individuals unable to undergo surgery.
Area of Science:
- Cardiology
- Valvular Heart Disease
Background:
- Degenerative mitral stenosis (DMS) arises from severe mitral annular calcification.
- Increasing life expectancy leads to more elderly patients with comorbidities and high surgical risk.
Purpose of the Study:
- To review the epidemiology, diagnosis, and treatment of degenerative mitral stenosis.
- To highlight the need for alternative percutaneous approaches for inoperable or high-risk DMS patients.
Main Methods:
- Literature review of current data on degenerative mitral stenosis.
- Analysis of diagnostic considerations and therapeutic strategies.
Main Results:
- DMS is a growing concern in developed nations, particularly among the elderly.
- Medical management is the primary therapy, but surgical options are limited by extensive calcification and patient comorbidities.
Conclusions:
- There is a critical need for innovative percutaneous treatment options for degenerative mitral stenosis.
- Current treatment focuses on medical management, delaying surgery until symptoms are severe.
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