Related Experiment Video
Updated: Mar 21, 2026
07:09
A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
2.5K
Targeting heart failure with preserved ejection fraction: current status and future prospects
Manreet Kanwar1, Claire Walter1, Megan Clarke1
1Department of Cardiology, Allegheny General Hospital, Pittsburgh, PA, USA.
Vascular Health and Risk Management
|May 5, 2016
Summary
Heart failure with preserved ejection fraction (HFpEF) is a major health issue with no approved treatments. Research is urgently needed to understand HFpEF causes and develop new therapies to improve patient outcomes.
Area of Science:
- Cardiology
- Clinical Medicine
- Translational Research
Background:
- Heart failure with preserved ejection fraction (HFpEF) presents a substantial challenge due to high prevalence, morbidity, mortality, and healthcare expenses.
- Significant gaps exist in understanding HFpEF pathophysiology, definition, and effective therapeutic targets.
Purpose of the Study:
- To highlight the urgent need for focused drug and device development for HFpEF.
- To emphasize the necessity of advancing the understanding of HFpEF pathophysiology.
Main Methods:
- Review of current literature and clinical trial landscape for HFpEF.
- Analysis of the unmet needs in HFpEF management.
Main Results:
- Currently, no therapies are approved to reduce mortality or hospitalizations in HFpEF patients.
- Several clinical trials are underway to address this therapeutic gap.
Conclusions:
- There is a critical need for accelerated drug and device development for HFpEF.
- Further research into HFpEF pathophysiology is essential for therapeutic advancements.
Related Concept Videos
01:17Pathophysiology of Heart Failure
4.5K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
4.5K
01:30Heart Failure IV: Classification and Diagnostic Evaluation
565
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
565
01:30Heart Failure V: Medical Management
506
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
506
01:29Heart Failure II: Pathophysiology
1.3K
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.3K
01:27Heart Failure I: Introduction
1.2K
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
1.2K
01:29Cardiomyopathy V: Interprofessional Care
605
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
605