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Updated: Mar 21, 2026
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
31.5K
Emerging Concepts on the Gut Microbiome and Multiple Sclerosis.
Justin D Glenn1, Ellen M Mowry1
1Division of Neuroimmunology and Neurological Infections, Department of Neurology, Johns Hopkins University , School of Medicine, Baltimore, Maryland.
Summary
The gut microbiota plays a crucial role in human health and immune development. This review explores the gut microbiome
Area of Science:
- Microbiome Research
- Neuroimmunology
- Human Health
Background:
- The human gut microbiota is essential for development, health, and immune system maturation.
- Gut microbes influence gut epithelial function, metabolism, and nutrition from birth.
- Dysregulated immune responses to self-tissue can cause autoimmune diseases like multiple sclerosis (MS).
Purpose of the Study:
- To review the role of gut bacteria and phages in the development of multiple sclerosis (MS).
- To examine associations between gut microbiota composition and MS.
- To discuss potential therapeutic strategies targeting the gut microbiota for MS.
Main Methods:
- Review of preclinical studies on gut microbiota and neuroinflammatory autoimmune diseases.
- Analysis of clinical investigations linking MS status to gut microbiota composition.
- Examination of current research on gut bacteria, phages, and MS pathogenesis.
Main Results:
- Preclinical models indicate gut microbiota are necessary for neuroinflammatory autoimmune disease.
- Clinical studies reveal correlations between MS and specific gut microbial compositions.
- Gut bacteria and their phages are implicated in MS development.
Conclusions:
- The gut microbiota significantly influences the immune system and may play a role in MS.
- Understanding the gut microbiome's composition is vital for MS research.
- Targeting the gut microbiota offers potential therapeutic avenues for managing MS.
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