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Functionalization of metal nanoclusters for biomedical applications
Xiao-Rong Song1, Nirmal Goswami, Huang-Hao Yang
1Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, 117585, Singapore. chexiej@nus.edu.sg.
The Analyst
|May 6, 2016
Summary
Surface functionalization enhances metal nanoclusters (NCs) for biomedical applications. This review covers strategies, applications, and the in vivo/in vitro fate of these advanced nanomaterials.
Area of Science:
- Nanomaterials Science
- Biomedical Engineering
- Surface Chemistry
Background:
- Metal nanoclusters (NCs) possess unique properties like luminescence and biocompatibility.
- Surface functionalization tailors NCs' stability, luminescence, and biodistribution.
- Functionalized NCs show promise for targeted biomedical applications.
Purpose of the Study:
- To review functionalization strategies for metal nanoclusters.
- To highlight biomedical applications of functionalized metal NCs.
- To discuss the in vitro and in vivo fate and toxicity of functionalized NCs.
Main Methods:
- Literature review of recent advancements in metal nanocluster functionalization.
- Analysis of studies focusing on biomedical applications.
- Comparative discussion of in vitro and in vivo behavior and toxicity.
Main Results:
- Various surface functionalization strategies have been developed for metal NCs.
- Functionalized NCs demonstrate potential in biological sensing, imaging, and therapy.
- Understanding in vitro/in vivo fate and toxicity is crucial for clinical translation.
Conclusions:
- Surface functionalization is key to unlocking the full biomedical potential of metal NCs.
- Further research is needed to address challenges in targeting, delivery, and safety.
- Future developments will focus on advanced functionalized NCs for personalized medicine.
