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Updated: Mar 21, 2026

Clinical Imaging of Microwave Mammography
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Performance evaluation of a high resolution dedicated breast PET scanner.

Trinitat García Hernández1, Aurora Vicedo González1, Jose Ferrer Rebolleda2

  • 1Department of Medical Physics, ERESA, Hospital General Universitario, Valencia 46014, Spain.

Medical Physics
|May 6, 2016
PubMed
Summary

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Dedicated breast PET (DbPET) scanners offer improved spatial resolution for detecting early-stage breast cancers compared to whole-body PET. The Mammi-PET system demonstrates high performance, accurately detecting small lesions with excellent resolution.

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Radiology

Background:

  • Whole-body PET (WB-PET) scans have limitations in detecting early-stage breast cancers due to lower spatial resolution.
  • Dedicated breast PET (DbPET) systems have been developed to enhance imaging of the breast with improved resolution.
  • Evaluating the performance of novel DbPET systems is crucial for clinical adoption.

Purpose of the Study:

  • To evaluate the performance of a high-resolution dedicated breast PET scanner, the Mammi-PET (Oncovision).
  • To assess the scanner's capabilities in terms of sensitivity, uniformity, energy, and spatial resolution.
  • To compare the lesion detectability of DbPET with WB-PET.

Main Methods:

  • Performance metrics including sensitivity, uniformity, and energy resolution were measured.

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  • Spheres of varying sizes (2.5-6 mm) and activity concentrations were embedded in a breast phantom to simulate lesions with different lesion-to-background ratios (LBR).
  • Reporter-based detection studies were conducted, varying acquisition time, LBR, sphere size, and reconstruction parameters, with comparisons to WB-PET scans.

    • Main Results:

    • The Mammi-PET system achieved a peak sensitivity of 2.0% and spatial resolution of 1.7-2.0 mm.
    • Excellent sphere detectability (100%) was achieved for spheres ≥4 mm with LBR ≥10 and acquisition times >3 min.
    • DbPET demonstrated superior lesion detectability compared to WB-PET for smaller lesions (≥5 mm) under specific acquisition conditions.

    Conclusions:

    • The Mammi-PET system exhibits good performance characteristics for clinical application in breast imaging.
    • The DbPET scanner offers improved spatial resolution and enhanced detectability of small breast lesions compared to WB-PET.
    • These findings support the clinical utility of dedicated breast PET imaging for early-stage breast cancer detection.