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Updated: Mar 21, 2026

Quantitative Fundus Autofluorescence for the Evaluation of Retinal Diseases
Published on: March 11, 2016
Ocular autofluorescence in diabetes mellitus. A review
Ana M Calvo-Maroto1, Rafael J Perez-Cambrodi2, Santiago Garcia-Lazaro1
1Optometry Research Group, Department of Optics and Optometry and Vision Sciences, University of Valencia, Valencia, Spain.
Abstract:
Diabetes mellitus is a metabolic disease with a considerable impact on healthcare owing to its increased prevalence and high mortality rate. Structural, morphological, and physiological changes in each of the ocular components have been described in detail. Autofluorescence has been described as a good indicator of metabolic activity. The aim of the present review is to provide an overview of ocular endogenous fluorophores in the cornea, the crystalline lens, and the retinal pigment epithelium, the effects of diabetes mellitus and therefore the potential of autofluorescence assessment for screening and monitoring changes in diabetic patients.
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