APPEARANCE OF NEURODEVELOPMENTAL DISORDERS IN CHILDREN DELIVERED POST-TERM: A CROSS-SECTION STUDY

Mladenka Vukojevic1, Ines Trninic2, Arta Dodaj3

  • 1Faculty of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina.

Insights

Post-term delivery, or prolonged pregnancy, is linked to neurodevelopmental disorders in children. Intellectual disability was the most frequent diagnosis observed in this study group.

Area of Science:

  • Pediatrics
  • Neurodevelopmental Disorders
  • Obstetrics

Background:

  • Neurodevelopmental disorders (NDDs) are a significant concern in child health.
  • The potential impact of prolonged pregnancy on child development requires further investigation.

Purpose of the Study:

  • To investigate the occurrence of NDDs in children born post-term.
  • To determine if prolonged pregnancy is a contributing factor to NDDs.

Main Methods:

  • A cohort of 34 children with NDDs born post-term was studied.
  • Data was collected over an 18-year period at a specialized clinic in Bosnia and Herzegovina.

Main Results:

  • The study observed a higher incidence of NDDs in males (59.4%) compared to females (40.6%).
  • Intellectual disability (38.2%) was the most prevalent NDD, followed by epilepsy (26.4%), delayed psychomotor development (14.7%), and cerebral palsy (11.7%).
  • A significant correlation was found between maternal parity and post-term delivery.

Conclusions:

  • Post-term delivery is suggested as a potential cause of neurodevelopmental disorders.
  • Intellectual difficulties represent the most common NDD associated with post-term births in this cohort.
Abstract

Related Concept Videos

Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Neurulation01:30

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
47.2K
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
1.3K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.2K
Development of the Oral Microbiota01:28

Development of the Oral Microbiota

The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
9