Related Experiment Videos
The inhibitory effect of gossypol on human sperm motility: relationship with time, temperature and concentration
1Department of Medicine, Taiwan Veterans General Hospital, Taipei, Republic of China.
Human Toxicology
|January 1, 1989
Abstract:
The inhibitory effect of gossypol acetic acid on human sperm motility was studied with a transmembrane migration method. Gossypol decreased sperm motility after it had been incubated with semen for more than 15 min. However, when sperm motility was evaluated immediately after semen had been mixed with gossypol, no inhibitory effect could be found. We consider that the sperm immobilizing potency of gossypol is much less than our previously studied sperm immobilizing agents. It is unlikely that gossypol can be developed as a vaginal spermicide. The importance of time course in the pharmacological study of sperm motility is emphasized in this study.
Keywords:
AsiaBiologyBody TemperatureChinaClinical ResearchContraceptionContraceptive AgentsContraceptive Agents, MaleContraceptive MethodsContraceptive Mode Of ActionDemographic FactorsDeveloping CountriesDiseasesEastern AsiaExaminations And DiagnosesFamily PlanningGenitaliaGerm CellsGossypolHuman VolunteersIn VitroInfectionsInhibition Of FertilizationLaboratory Examinations And DiagnosesLaboratory ProceduresMethodological StudiesPhysiologyPopulationPopulation DynamicsReproductive Tract InfectionsResearch MethodologySexually Transmitted DiseasesSperm CountSperm Immobilizing AgentsSperm Transport InhibitionSpermatozoaSpermicidal Contraceptive AgentsTaiwanTime FactorsUrogenital SystemVaginal Spermicides