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Updated: Jul 23, 2026
Electroactive Polymer Nanoparticles Exhibiting Photothermal Properties
Published on: January 8, 2016
A photothermally responsive nanoprobe for bioimaging based on Edman degradation
Yi Liu1, Zhantong Wang2, Huimin Zhang2
1China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China. maqj@jlu.edu.cn and Laboratory of Molecular Imaging and Nanomedicine (LOMIN), National Institute of Biomedical Imaging and Bioengineering (NIBIB), National Institutes of Health (NIH), Bethesda, Maryland 20892, USA. dkiesewetter@mail.nih.gov shawn.chen@nih.gov.
None:
A new type of photothermally responsive nanoprobe based on Edman degradation has been synthesized and characterized. Under irradiation by an 808 nm laser, the heat generated by the gold nanorod core breaks the thiocarbamide structure and releases the fluorescent dye Cy5.5 with increased near-infrared (NIR) fluorescence under mild acidic conditions. This RGD modified nanoprobe is capable of fluorescence imaging of ανβ3 over-expressing U87MG cells in vitro and in vivo. This Edman degradation-based nanoprobe provides a novel strategy to design activatable probes for biomedical imaging and drug/gene delivery.
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