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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence
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Closure of a Patent Foramen Ovale PFO: An Intervention Sequence

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Patent Foramen Ovale: Stroke and Device Closure

Hussam S Suradi1, Ziyad M Hijazi2

  • 1Interventional Cardiology, Rush Center for Congenital & Structural Heart Disease, Rush University Medical Center, 1653 W Congress Pkwy, Chicago, IL 60612, USA; Department of Cardiology, St Mary Medical Center, Community HealthCare Network, Community Healthcare System, 1500 South Lake Park Avenue, Suite 110, Hobart, IN 46342, USA.

Cardiology Clinics
|May 7, 2016
PubMed

Insights

Patent foramen ovale (PFO) is linked to cryptogenic stroke. This review examines PFO closure device efficacy for preventing recurrent strokes, despite ongoing debate.

Area of Science:

  • Cardiology
  • Neurology
  • Medical Devices

Background:

  • Patent foramen ovale (PFO) is a common cardiac anomaly in adults.
  • PFO is frequently associated with cryptogenic stroke, a stroke of unknown cause.
  • Microemboli traversing a PFO are hypothesized to cause stroke.

Purpose of the Study:

  • To review the association between PFO and cryptogenic stroke.
  • To evaluate the current evidence for PFO device closure in stroke prevention.

Main Methods:

  • Literature review of studies and randomized trials.
  • Analysis of the association between PFO and stroke pathogenesis.
  • Assessment of PFO closure device efficacy.

Main Results:

  • Numerous studies and trials have investigated PFO closure for stroke prevention.
  • Significant debate continues regarding the definitive efficacy of PFO closure.
  • Medical therapy and PFO closure are proposed treatment options.

Conclusions:

  • The role of PFO in cryptogenic stroke remains a subject of ongoing research and clinical debate.
  • Evidence for PFO device closure in reducing recurrent stroke risk is still being established.

Keywords:
Closure devicesCryptogenic strokePatent foramen ovaleShunt closureTransient ischemic attack

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