Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

2.9K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.9K
Teratogenicity01:07

Teratogenicity

4.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
4.5K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.9K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.9K
Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

7.0K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
7.0K
Infertility in Females01:28

Infertility in Females

5.0K
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
5.0K
Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

1.9K
Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same authorSame journal

Mechanical thromboprophylaxis for preventing intradialytic hypotension in people undergoing maintenance haemodialysis.

The Cochrane database of systematic reviews·2026
Same author

Congenital Heart Defects, Special Needs, and Developmental Vulnerability in Singleton Children at School Age: A Population-Based Data Linkage Study.

Journal of the American Heart Association·2026
Same author

Clinical effectiveness of telepharmacy services in patients with non-communicable diseases in ambulatory care settings.

The Cochrane database of systematic reviews·2026
Same author

Sustained and indirect effects of PCV10 reduced-dose schedules on pneumococcal carriage in Viet Nam: a long-term follow-up of a cluster-randomised controlled trial.

The Lancet. Infectious diseases·2026
Same author

Standardised reporting framework for nutrition and growth in preterm nutrition studies: the NutriGrow Delphi study.

Pediatric research·2026
Same author

Pain Assessment Tools for Infants, Children, and Adolescents With Cancer: A Scoping Review.

Pediatrics international : official journal of the Japan Pediatric Society·2026

Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

835

Vitamin supplementation for preventing miscarriage.

Olukunmi O Balogun1, Katharina da Silva Lopes, Erika Ota

  • 1Department of Health Policy, National Center for Child Health and Development, Medical Building No. 2, Hongo Campus, 2-10-1 Okura, Tokyo, Tokyo, Japan, 157-8535.

The Cochrane Database of Systematic Reviews
|May 7, 2016
PubMed
Summary
This summary is machine-generated.

Vitamin supplementation before or during early pregnancy does not prevent miscarriage. However, multivitamins with iron and folic acid may reduce stillbirth risk.

More Related Videos

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

4.0K
Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

13.3K

Related Experiment Videos

Last Updated: Mar 21, 2026

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes
03:19

Author Spotlight: Studying the Impact of Maternal Dietary Deficiencies on Long-Term Offspring Health Outcomes

Published on: June 28, 2024

835
Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage
05:16

Multiplexed Fluorescent Immunohistochemical Staining of Four Endometrial Immune Cell Types in Recurrent Miscarriage

Published on: August 4, 2021

4.0K
Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer
09:52

Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer

Published on: April 26, 2018

13.3K

Area of Science:

  • Obstetrics and Gynecology
  • Nutritional Science
  • Reproductive Health

Background:

  • Miscarriage is a common pregnancy complication linked to various factors, including poor vitamin intake.
  • Vitamin supplementation before or during early pregnancy is explored as a potential miscarriage prevention strategy.

Purpose of the Study:

  • To evaluate the effectiveness and safety of vitamin supplementation in preventing spontaneous miscarriage.

Main Methods:

  • Systematic review and meta-analysis of 40 randomized and quasi-randomized controlled trials.
  • Included trials involved supplementation starting before 20 weeks gestation.
  • Data extraction and quality assessment using the GRADE approach.

Main Results:

  • No significant reduction in miscarriage risk was observed with vitamin C, vitamin A, or folic acid supplementation alone or in combination.
  • Multivitamin supplementation with iron and folic acid showed a statistically significant reduction in stillbirth risk (RR 0.92, 95% CI 0.85 to 0.99).
  • Limited evidence suggested potential benefits for total fetal loss with certain multivitamin combinations, but these require cautious interpretation due to small sample sizes.

Conclusions:

  • General vitamin supplementation prior to or in early pregnancy does not prevent miscarriage.
  • Multivitamins combined with iron and folic acid demonstrated a reduced risk of stillbirth.
  • Further research is needed to clarify the effects of specific vitamin combinations on miscarriage and related outcomes.