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Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
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Advances and perspectives in tooth tissue engineering.

Nelson Monteiro1, Pamela C Yelick1

  • 1Department of Oral and Maxillofacial Pathology, Tufts University, Boston, MA, USA.

Journal of Tissue Engineering and Regenerative Medicine
|May 7, 2016
PubMed
Summary
This summary is machine-generated.

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Bio-engineered teeth offer a permanent alternative to prosthetic options like dental implants. Advances in biomaterials and stem cell technology are key to developing functional, natural-like teeth through tissue engineering.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Engineering

Background:

  • Current prosthetic teeth, such as dental implants, have limitations.
  • Developing bio-engineered teeth requires mimicking natural tooth structure and mechanical properties.
  • Tooth regeneration research focuses on molecular and nanoscale biomimetic systems.

Purpose of the Study:

  • To review recent advances in tooth tissue engineering.
  • To discuss the use of biomimetic scaffolds in dental regeneration.
  • To highlight the role of stem cells and bioactive agents in creating functional bio-engineered teeth.

Main Methods:

  • Utilizing biomaterials to create scaffolds with architectural cues.
  • Employing drug delivery systems for controlled release of bioactive agents (growth factors, nucleic acids).
Keywords:
bio-active agentsscaffoldstem cells, drug delivery systemsteethtissue engineering

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  • Investigating the use of dental stem cells for proliferation and differentiation.

    • Main Results:

    • Biomimetic scaffolds can support dental stem cell functions.
    • Spatiotemporal control of bioactive agent release is achievable.
    • In vitro and in vivo studies show promising results for tooth regeneration.

    Conclusions:

    • Tooth tissue engineering holds potential for permanent tooth replacement.
    • Further research is needed to optimize methods using adult human dental stem cells.
    • Generating bio-engineered teeth of predetermined size and shape requires further development.