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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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A Biomimetic Model for Liver Cancer to Study Tumor-Stroma Interactions in a 3D Environment with Tunable Bio-Physical Properties
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Modeling tumor microenvironments using custom-designed biomaterial scaffolds.

Zen Liu1, Gordana Vunjak-Novakovic2

  • 1Department of Biomedical Engineering, Columbia University in the City of New York.

Current Opinion in Chemical Engineering
|May 7, 2016
PubMed
Summary
This summary is machine-generated.

Tissue engineering uses custom biomaterial scaffolds to model tumors, offering better insights into cancer progression and resistance than traditional methods. This approach aids in discovering new therapeutic targets and treatments.

Keywords:
Biomaterialscancerscaffoldtissue engineeringtumor models

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Area of Science:

  • Biomaterials Science
  • Cancer Biology
  • Tissue Engineering

Background:

  • The tumor microenvironment significantly influences cancer formation, progression, and metastasis.
  • Traditional monolayer cell cultures do not fully represent the complex tumor ecosystem.
  • Understanding tumor-environment interactions is crucial for effective cancer therapy.

Purpose of the Study:

  • To review recent advancements in using custom-designed biomaterial scaffolds for modeling human tumors.
  • To highlight the potential of tissue engineering in cancer research.
  • To explore how biomaterial scaffolds can improve the study of tumor biology.

Main Methods:

  • Review of current literature on tissue engineering and cancer modeling.
  • Focus on the design and application of custom biomaterial scaffolds.
  • Analysis of how these scaffolds recapitulate the native tumor environment.

Main Results:

  • Biomaterial scaffolds offer a more physiologically relevant model of the tumor microenvironment.
  • Studying cancer in engineered scaffolds can reveal novel therapeutic targets.
  • Tissue engineering approaches promise more reliable drug development and research outcomes.

Conclusions:

  • Custom-designed biomaterial scaffolds are a powerful tool for advancing cancer research.
  • These engineered models enhance our understanding of tumor progression and resistance mechanisms.
  • Tissue engineering holds significant potential to impact clinical practice and drug discovery.