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lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...

lncRNA - Long Non-coding RNAs

lncRNA - Long Non-coding RNAs

Alternative RNA Splicing

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The physiological function of a cell and cellular communication are outcomes of a range of extrinsic signals, intracellular signaling pathways, and cellular responses. No two cell types express the same repertoire of signaling components. Receptors are highly selective for their cognate ligands, but once activated, they can alter multiple cellular processes such as DNA transcription, protein synthesis, and metabolic activity.
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Related Experiment Video

Updated: Mar 21, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

Published on: November 11, 2014

Divergent Paths Lnc Cell Fates.

Samir Ounzain¹, Thierry Pedrazzini¹

¹Experimental Cardiology Unit, Department of Medicine, University of Lausanne Medical School, 1011 Lausanne, Switzerland.

|May 7, 2016

Summary

This summary is machine-generated.

Specific long noncoding RNAs (lncRNAs) activate key developmental genes. These regulatory molecules control embryonic stem cell fate and properties, offering new insights into stem cell biology.

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Last Updated: Mar 21, 2026

Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis

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Published on: November 11, 2014

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Published on: April 10, 2018

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Area of Science:

Molecular Biology
Genetics
Stem Cell Biology

Background:

Long noncoding RNAs (lncRNAs) are recognized as crucial regulators of gene expression.
Their role in controlling stem cell properties is an area of active investigation.
Understanding lncRNA function is key to deciphering stem cell differentiation and development.

Purpose of the Study:

To investigate the function of a specific class of lncRNAs in embryonic stem cell regulation.
To determine how divergently transcribed lncRNAs influence stem cell fate.
To identify the mechanisms by which lncRNAs activate developmental genes.

Main Methods:

Analysis of lncRNA transcription patterns in embryonic stem cells.
Functional studies to assess the impact of specific lncRNAs on gene expression.
Investigation of lncRNA interactions with key developmental genes.

Main Results:

A distinct group of lncRNAs, transcribed divergently from protein-coding genes, was identified.
These lncRNAs were shown to activate critical developmental genes essential for stem cell fate.
The study provides evidence for a novel regulatory mechanism involving lncRNAs in stem cell differentiation.

Conclusions:

Divergent lncRNAs play a significant role in controlling embryonic stem cell fate.
These lncRNAs act by activating key developmental genes, thereby regulating stem cell properties.
The findings expand our understanding of the regulatory landscape governing stem cell pluripotency and differentiation.