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Related Concept Videos

Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

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Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
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Nervous Tissue: Myelin01:25

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The myelin sheath is a multilayered lipid and protein covering that insulates the axon of a neuron, enhancing the speed of nerve impulse conduction. Axons without this sheath are referred to as unmyelinated. Two types of neuroglia, Schwann cells in the peripheral nervous system (PNS) and oligodendrocytes in the central nervous system (CNS) are responsible for producing myelin sheaths.
Schwann cells begin to form myelin sheaths around axons during fetal development. They wrap around a small...
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Neurogenesis and Regeneration of Nervous Tissue01:15

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Neurons: The Cell Body and the Dendrites01:23

Neurons: The Cell Body and the Dendrites

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A typical nerve cell comprises three main components: the cell body, dendrites, and the axon. The cell body, also known as the soma or perikaryon, serves as the central biosynthetic hub housing a nucleus surrounded by cytoplasm containing organelles commonly found in most cells. Notably, Nissl bodies, clusters of the rough endoplasmic reticulum and free ribosomes responsible for protein synthesis, are distinctive features of the neuronal cell body. As neurons age, aggregates of a brown pigment...
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Neuron Structure01:31

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Related Experiment Video

Updated: Mar 21, 2026

Application of MultiColor FlpOut Technique to Study High Resolution Single Cell Morphologies and Cell Interactions of Glia in Drosophila
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Glia Get Neurons in Shape.

Lu O Sun1, Ben A Barres1

  • 1Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|May 7, 2016
PubMed
Summary

Glial cells in C. elegans shape sensory neuron terminals to control temperature sensing behaviors. This study reveals the cellular and molecular mechanisms behind this crucial nervous system function.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Developmental Biology

Background:

  • Glial cells are crucial for nervous system function, supporting neuronal health and activity.
  • Sensory neurons require precise structural organization for effective signal transduction.
  • Thermosensing, the ability to detect temperature, is vital for organismal survival and behavior.

Purpose of the Study:

  • To investigate the role of glial cells in shaping sensory neuron architecture.
  • To elucidate the cellular and molecular mechanisms by which glia influence neuronal structure.
  • To understand how glial-mediated neuronal shaping impacts thermosensing behavior in C. elegans.

Main Methods:

  • Utilized genetic screening and live imaging in Caenorhabditis elegans.

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Last Updated: Mar 21, 2026

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  • Employed high-resolution microscopy to visualize glial-neuronal interactions.
  • Performed behavioral assays to assess thermosensing capabilities.

    • Main Results:

    • Identified specific glial cell types and molecular pathways involved in shaping sensory neuron terminals.
    • Demonstrated that glial interactions directly influence the morphology of thermosensory neuron endings.
    • Showcased a direct correlation between glial-mediated structural changes and thermosensing behavior.

    Conclusions:

    • Glial cells actively sculpt sensory neuron terminals, playing a critical role in nervous system development and function.
    • The study provides novel insights into the cellular and molecular basis of glial-neuronal interactions.
    • Understanding these mechanisms offers potential avenues for addressing neurological disorders involving sensory processing.