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Updated: Mar 21, 2026

Stimulation of Cytoplasmic DNA Sensing Pathways In Vitro and In Vivo
Published on: September 18, 2014
The role of cGAS in innate immunity and beyond
Andrea Ablasser1, Muhammed F Gulen2
1Global Health Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland. andrea.ablasser@epfl.ch.
Abstract:
The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases and controls immune responses that underlie cancer immunosurveillance. In this review, we highlight our current understanding of DNA sensing by cGAS and its involvement in human disease.
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