The Role of PET/CT in Advanced Malignant Melanoma

Positron emission tomography/computed tomography (PET/CT) with fluorodeoxyglucose demonstrates a high sensitivity and specificity for detecting both locoregional and distant metastases in patients presenting with AJCC stages III and IV disease. PET/CT also plays an important role in the detection of recurrence particularly in high-risk group patients, and this should be the modality of choice in investigating patients for suspected recurrence. The role of PET/CT in response assessment and follow-up still has to be defined, and cost-effectiveness analysis is required to strengthen its role.