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Related Concept Videos

Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Mar 21, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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Recurrence of Melanoma.

Sergi Vidal-Sicart1, Domenico Rubello2, Francesca Pons3

  • 1Department of Nuclear Medicine, Hospital Clínic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Villarroel 170, 08036 Barcelona, Spain; Department of Nuclear Medicine, CRC-MAR, Corporació Sanitària. Passeig Marítim 25, 08003 Barcelona, Spain.

PET Clinics
|May 10, 2016
PubMed
Summary

Detecting cutaneous melanoma recurrence involves various imaging methods. (18)F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) aids in assessing disease spread and node involvement, complementing other diagnostic tools for effective patient follow-up.

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Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiology

Background:

  • Cutaneous melanoma recurrence requires accurate detection and staging.
  • Various imaging modalities are employed for surveillance and diagnosis.
  • Positron Emission Tomography (PET) offers functional imaging insights.

Purpose of the Study:

  • To evaluate the role of imaging techniques in detecting cutaneous melanoma recurrence.
  • To assess the utility of (18)F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in melanoma follow-up.
  • To compare different imaging modalities for staging and disease assessment.

Main Methods:

  • Review of imaging techniques for melanoma recurrence.
  • Discussion of FDG-PET, ultrasonography, and PET/computed tomography (CT) utility.
  • Comparison with sentinel node biopsy as the gold standard for nodal assessment.

Main Results:

  • FDG-PET is valuable for assessing disease recurrence and metastatic sites.
  • Ultrasonography and FDG-PET assist in evaluating regional lymph node involvement.
  • PET/CT is crucial for pre-metastasectomy staging and clarifying suspicious CT findings.

Conclusions:

  • Imaging plays a critical role in managing suspected cutaneous melanoma recurrence.
  • (18)F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) is an important tool in this clinical setting.
  • A combination of imaging techniques, alongside sentinel node biopsy, ensures comprehensive disease evaluation.