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Updated: Mar 21, 2026

Examining BCL-2 Family Function with Large Unilamellar Vesicles
Published on: October 5, 2012
BOK: Oddball of the BCL-2 Family
Elizabeth A Brem1, Anthony Letai2
1Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, MA.
Abstract:
BOK is a BCL-2 family member whose function has been difficult to elucidate. It has been recently demonstrated that BOK is regulated by the endoplasmic reticulum associated-degradation (ERAD) pathway, can induce mitochondrial outer membrane permeabilization (MOMP), and is not regulated by other members of the BCL-2 family. These findings demonstrate a novel mechanism for regulation of apoptosis, but it remains unclear in which specific contexts this mechanism may be most essential for cell death.
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