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Review of Clinical Applications of Fluorodeoxyglucose-PET/Computed Tomography in Pediatric Patients with Lymphoma
Gang Cheng1, Scott R Akers1, Hongming Zhuang2
1Department of Radiology, Philadelphia VA Medical Center, 3900 Woodland Avenue, Philadelphia, PA 19104, USA.
Abstract:
[(18)F]fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) imaging is routinely used in the initial diagnosis and response assessment during and immediately after therapy, as well as in the follow-up surveillance. FDG PET/CT outperforms diagnostic CT and other conventional imaging modalities in the evaluation of pediatric patients with lymphoma, with higher sensitivity and specificity, leading to more accurate staging/restaging and modifications of therapeutic strategies. Resolution of FDG-avid lesions in the early post-therapy phase often indicates good response to treatment and better prognosis. FDG PET/CT also outperforms bone marrow biopsy in detecting bone marrow infiltration of lymphoma.
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