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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Bone Cells and Tissue01:30

Bone Cells and Tissue

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Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Related Experiment Video

Updated: Mar 21, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Osteoclast function and bone-resorbing activity: An overview.

Niroshani Surangika Soysa1, Neil Alles2

  • 1Pharmacology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.

Biochemical and Biophysical Research Communications
|May 10, 2016
PubMed
Summary
This summary is machine-generated.

Osteoclasts drive bone resorption, crucial for skeletal health and disease. Understanding their function aids in developing treatments for bone diseases like osteoporosis.

Keywords:
Actin ring formationBone resorptionOsteoclast activityPodosome

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Area of Science:

  • Cell Biology
  • Skeletal Biology
  • Pathology

Background:

  • Bone resorption is a vital cellular process for skeletal development and adult bone remodeling.
  • Increased osteoclast activity underlies pathological bone conditions such as osteoporosis, leading to excessive bone resorption.
  • Decades of research have elucidated intracellular mechanisms governing osteoclast bone-resorbing activity.

Purpose of the Study:

  • To review and synthesize current literature on osteoclast function.
  • To examine the mechanisms of osteoclast-induced bone resorption.
  • To explore factors modulating osteoclast activity for therapeutic insights.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of intracellular pathways in osteoclasts.
  • Examination of cytokines and signaling molecules influencing osteoclast activity.

Main Results:

  • Osteoclast function is critical for bone homeostasis and disease.
  • Intracellular signaling pathways are well-defined but require continued investigation.
  • Cytokines and other factors significantly modulate osteoclast bone-resorbing capacity.

Conclusions:

  • A comprehensive understanding of osteoclast biology is essential for addressing bone resorption disorders.
  • Targeting osteoclast activity offers a promising therapeutic strategy for osteoporosis and related diseases.
  • Further research into modulators of osteoclast function can accelerate drug development for skeletal pathologies.