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Updated: Mar 21, 2026

Multi-photon Imaging of Tumor Cell Invasion in an Orthotopic Mouse Model of Oral Squamous Cell Carcinoma
Published on: July 25, 2011
New Tracers PET in Head and Neck Squamous Cell Carcinoma
Tony J C Wang1, Yusuf Menda2, Simon K Cheng1
1Department of Radiation Oncology, College of Physicians and Surgeons, Columbia University, 622 West 168th Street, New York, NY 10032, USA.
Abstract:
PET is commonly used in the evaluation and posttreatment management of head and neck squamous cell carcinoma. Although [(18)F]fluorodeoxyglucose is the most commonly used radiopharmaceutical, many other radiopharmaceuticals are under investigation to assess particular biologic characteristics such as hypoxia and tumor repopulation. In this review, the authors discuss new PET tracers that allow the biologic profiling of head and neck squamous cell carcinomas, including [(18)F]fluoromisonidazole, [(18)F]fluorothymidine, [(18)F]fluoromethyltyrosine, and epidermal growth factor receptor biomarkers.
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