Related Experiment Video
Updated: Mar 21, 2026
06:25
Fabrication of a Master Mold for Microneedles with a Micron-sized Air-vent Hole
Published on: December 5, 2025
510
A fabrication method of microneedle molds with controlled microstructures
Qi Lei Wang1, Dan Dan Zhu1, Yang Chen1
1Beijing Laboratory of Biomedical Materials, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China.
Summary
This study presents a novel laser micro-machining method for fabricating microneedle (MN) molds. This technique allows precise control over microstructure fabrication, enabling the production of sharp, skin-penetrating polymer microneedles for enhanced drug delivery.
Area of Science:
- Biomaterials Engineering
- Drug Delivery Systems
- Nanotechnology
Background:
- Microneedles (MNs) provide a minimally invasive method for transdermal drug delivery.
- Conventional polymer MN fabrication relies on micromolding, which has limitations in controlling MN structure and sharpness.
Purpose of the Study:
- To develop a novel fabrication method for microneedle molds with controlled microstructures.
- To enable the production of polymer microneedles with precise geometries and improved sharpness.
Main Methods:
- Laser micro-machining was employed to create microneedle molds on PDMS sheets.
- Microstructure control was achieved by adjusting laser parameters and imported patterns.
Main Results:
- The laser micro-machining method allows precise control over microneedle mold microstructures.
- Microneedles fabricated using these molds demonstrated sufficient sharpness for skin penetration.
Conclusions:
- This scalable fabrication method for microneedle molds offers enhanced control over microneedle geometry.
- The developed technique is promising for future advancements in polymer microneedle-based drug delivery applications.
