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Related Concept Videos

Transdermal Drug Delivery Systems01:18

Transdermal Drug Delivery Systems

Transdermal drug delivery systems (TDDS) enable the controlled release of drugs across the skin into systemic circulation. They are particularly advantageous for drugs with short half-lives or narrow therapeutic indices, as they maintain consistent plasma concentrations and reduce the risk of subtherapeutic or toxic levels.TDDS are categorized into monolithic, reservoir, and mixed systems. Monolithic systems embed the drug in a polymer matrix, where diffusion governs release. Reservoir systems...

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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
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Transdermal hydrogen therapy for psoriasis using cavity-embedded double-conical microneedles.

Dan Dan Zhu1, Ryan Yi Da Lim2, Yu Lin Poh1

  • 1School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 637457, Singapore.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|October 13, 2025
PubMed
Summary
This summary is machine-generated.

A novel microneedle therapy delivers molecular hydrogen transdermally, effectively treating psoriasis by reducing inflammation and oxidative stress. This innovative approach offers a promising alternative to current topical treatments for inflammatory skin diseases.

Keywords:
Hydrogen therapyInflammationMicroneedleOxidative stressPsoriasisTransdermal delivery

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Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Materials Science

Background:

  • Psoriasis is a chronic inflammatory skin condition with complex causes, currently lacking a definitive cure.
  • Existing topical treatments for psoriasis have limitations in skin penetration and can cause adverse effects.
  • The interplay between oxidative stress and inflammation is a key factor in psoriasis development.

Purpose of the Study:

  • To develop and evaluate a novel transdermal hydrogen therapy for psoriasis.
  • To investigate the potential of microneedle technology for delivering molecular hydrogen into the skin.
  • To assess the efficacy of this new therapy compared to standard treatments.

Main Methods:

  • Design of a double-conical microneedle for efficient delivery of magnesium hydride (MgH2) powder.
  • Development of a transdermal system for sustained release of molecular hydrogen within skin tissue.
  • Comparative study of the transdermal hydrogen therapy against calcipotriol cream in a psoriasis model.

Main Results:

  • The transdermal hydrogen therapy significantly reduced oxidative damage and pro-inflammatory cytokine expression.
  • Microneedle treatment effectively decreased immune cell infiltration and keratinocyte hyperproliferation.
  • The novel therapy demonstrated superior clinical outcomes compared to calcipotriol cream, alleviating systemic symptoms.

Conclusions:

  • Transdermal hydrogen therapy using microneedles is a promising, minimally invasive treatment for psoriasis.
  • This approach effectively targets the core mechanisms of psoriasis, including oxidative stress and inflammation.
  • Microneedle-based transdermal delivery represents a new strategy for treating inflammatory skin diseases.