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False Positive Lyme Disease IgM Immunoblots in Children
Paul M Lantos1, Susan C Lipsett2, Lise E Nigrovic2
1Division of General Internal Medicine and Division of Pediatric Infectious Diseases, Duke University Medical Center, Durham, NC.
The Journal of Pediatrics
|May 10, 2016
Abstract:
In our cross-sectional sample of 7289 serologic tests for Lyme disease, we identified 167 instances of a positive IgM immunoblot but a negative IgG immunoblot test result. Considering that only 71% (95% CI 64%-78%) of patients had Lyme disease, a positive IgM immunoblot alone should be interpreted with caution to avoid over-diagnosis of Lyme disease.

