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Bin Kong¹, Gan-Bin Liu², Jun-Ai Zhang³

¹Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics No. 1 Xincheng Road, Dongguan 523808, China.

American Journal of Translational Research

|May 10, 2016

Abstract:

Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB). In the current study, we demonstrated that ATB patients exhibited increases in serum IL-35 and in mRNA expression of both subunits of IL-35 (p35 and EBI3) in white blood cells and peripheral blood mononuclear cells. Consistently, anti-TB drug treatment led to reduction in serum IL-35 level and p35 or EBI3 expression. TB infection was associated with expression of p35 or EBI3 protein in CD4(+) but not CD8(+) T cells. Most p35(+)CD4(+) T cells and EBI3(+)CD4(+) T cells expressed Treg-associated marker CD25. Our findings may be important in understanding immune pathogenesis of TB. IL-35 in the blood may potentially serve as a biomarker for immune status and prognosis in TB.

Keywords:

CD4+CD25+ T cells EBI3 Human active pulmonary tuberculosis interleukin-35 p35

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