[Comparative clinical and cytological studies on the local tissue toxicity of fluoride gels]

Local short term and long term topical applications of a sodium fluoride jelly and an aminofluoride jelly were tested in a comparative clinical and cytological study of the reaction of the alveolar mucosa and the attached gum. Neither after short term use (single application) nor after long term use (four times continuous daily application) of the fluoride jelly was any change detected in the oral mucosa or gingiva. No clinically manifest epithelial damage or changes in cytology were observed outside the range of normal variations.