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Updated: Mar 21, 2026

Ultrasonic Assessment of Myocardial Microstructure
Published on: January 14, 2014
Assessment of myocardial performance index in hypertensive patients with or without hyperuricaemia
Cengiz Basar, Feyzullah Besli1, Hakan Ozhan
1Department of Cardiology, University School of Medicine Hospital,, Sanliurfa.. feyzullahbesli@gmail.com.
Background:
Myocardial performance index (MPI) is impaired in patients with hypertension. Uric acid is biologically active and can stimulate oxidative stress, endothelial dysfunction, inflammation, and vasoconstriction. Hyperuricaemia may provide a negative contribution to impaired MPI in hypertension.
Aim:
The study was designed to assess the MPI in hypertensive patients with or without hyperuricaemia.
Methods:
A total of 96 consecutive hypertensive patients were divided into two groups according to levels of serum uric acid (SUA); 49 normouricaemic patients (defined as SUA < 7.0 mg/dL in men and < 6.0 mg/dL in women) and 47 hyperuricaemic patients. SUA levels and other biochemistry parameters were determined by a standard analytical technique. All patients were evaluated by two-dimensional and Doppler echocardiography.
Results:
The two groups were similar according to age, body mass index, and smoking status. Mean MPI value (0.498 ± 0.06 vs. 0.410 ± 0.05, p < 0.001) was significantly higher in the hyperuricaemic group than the normouricaemic individuals and positively correlated with the mean value of SUA levels (r = 0.51, p < 0.001).
Conclusions:
Our study demonstrated that high SUA levels were significantly associated with impaired MPI in hypertensive patients. SUA may suggest a valuable laboratory finding in assessing the risk of developing subclinical impaired left ventricular global function.
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