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Updated: Mar 21, 2026
Deep Brain Stimulation with Simultaneous fMRI in Rodents
Published on: February 15, 2014
Anterior Thalamic Deep Brain Stimulation: Functional Activation Patterns in a Large Animal Model
William S Gibson1, Erika K Ross1, Seong Rok Han2
1Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Deep brain stimulation (DBS) of the anterior thalamic nucleus (ATN) activates brain networks, including the Papez circuit. This parameter-dependent activation in swine may inform epilepsy treatment strategies.
Area of Science:
- Neuroscience
- Medical Imaging
- Neurosurgery
Background:
- Deep brain stimulation (DBS) targets neural circuits for seizure control.
- The precise networks modulated by anterior thalamic nucleus (ATN) DBS are not fully understood.
Purpose of the Study:
- To investigate the network effects of ATN DBS using 3-T fMRI in a large animal model.
- To characterize the impact of varying stimulation parameters on brain activity.
Main Methods:
- Swine underwent ATN DBS with parameters from the SANTE trial.
- Blood oxygen level-dependent (BOLD) signals were measured while varying stimulation amplitude, frequency, and pattern.
Main Results:
- ATN DBS induced activation in cortical regions, including temporal, prefrontal, and sensorimotor areas.
- A dose-dependent increase in activation volume was observed at 60 Hz and 145 Hz stimulation.
Conclusions:
- ATN DBS in swine elicits parameter-dependent cortical activation, involving the Papez circuit.
- These findings suggest potential applications for epilepsy treatment, even with extratemporal seizure origins.
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