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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
[Nephrological problems in patients with diabetes]
Maciej Graczyk1, Joanna Matuszkiewicz-Rowińska1, Mirosław Jędras1
1Katedra i Klinika Nefrologii, Dializoterapii i Chorób Wewnętrznych, Warszawski Uniwersytet Medyczny, Warszawa.
Diabetic kidney disease is a major cause of kidney failure in diabetic patients. This review covers diabetic kidney disease, urinary tract infections, and asymptomatic bacteriuria in diabetes management.
Area of Science:
- Nephrology
- Diabetology
- Urology
Context:
- Diabetes mellitus is a prevalent condition associated with significant renal and urinary tract complications.
- Diabetic kidney disease (DKD) represents the most critical complication, being the primary driver of end-stage renal disease.
- Physicians frequently encounter other urinary tract issues in diabetic patients, including infections and asymptomatic bacteriuria.
Purpose:
- To provide a concise review of common kidney and urinary tract diseases in patients with diabetes mellitus.
- To highlight the significance of diabetic kidney disease as a leading cause of end-stage renal failure.
- To briefly discuss urinary tract infections and asymptomatic bacteriuria in the context of diabetes.
Summary:
- Diabetic kidney disease is the foremost cause of end-stage renal failure in individuals with diabetes mellitus.
- Urinary tract infections and asymptomatic bacteriuria are also common clinical issues observed in this patient population.
- This review synthesizes key information on these prevalent renal and urinary complications of diabetes.
Impact:
- Enhances understanding of the spectrum of kidney and urinary tract diseases in diabetes.
- Informs clinical practice regarding the diagnosis and management of these common diabetic complications.
- Underscores the importance of addressing renal health in the comprehensive care of diabetic patients.
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