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Updated: Aug 16, 2026

An Intact Pericardium Ischemic Rodent Model
Published on: September 2, 2021
Pericardial hyperechogenicity and "comets" in patients with acute pericarditis but no pericardial effusion: a
Daniele Sartorio1, Carmine Siniscalchi, Claudio Reverberi
1. ngaibazzi@gmail.com.
Insights
Echocardiography may reveal "pericardial comets" in acute pericarditis patients. While more frequent in those with pericarditis, this finding has limited clinical use due to its presence in healthy young individuals.
Area of Science:
- Cardiology
- Diagnostic Imaging
- Medical Ultrasound
Background:
- Acute pericarditis diagnosis is primarily clinical.
- Echocardiographic findings lack strong association with acute pericarditis, excluding pericardial effusion.
- Novel echocardiographic markers like pericardial hyperechogenicity and
- pericardial comets
- were hypothesized to be associated with acute pericarditis.
Purpose of the Study:
- To investigate the association between pericardial hyperechogenicity and "pericardial comets" with acute pericarditis.
- To compare echocardiographic findings in pericarditis patients versus healthy controls.
Main Methods:
- Retrospective analysis of echocardiograms from patients under 50 with confirmed pericarditis.
- Comparison with two healthy control groups (under and over 50 years old).
Main Results:
- No significant difference in hyperechogenicity or comets between pericarditis and age-matched controls (<50 years).
- Elderly controls (>50 years) showed significantly lower prevalence of hyperechogenicity and comets.
- Patients with pericarditis had a significantly higher prevalence of at least 2 pericardial comets (68%) compared to age-matched controls (48%).
Conclusions:
- Pericardial hyperechogenicity and comets are age-influenced, inversely proportional to age.
- At least 2 pericardial comets are more frequent in pericarditis patients than age-matched controls.
- The clinical utility of "pericardial comets" is limited by their frequent detection in healthy young individuals.
Background And Aim:
According to the published data and guidelines the diagnosis of pericarditis is mainly clinical; if we exclude patients with pericardial effusion, no single study has been able to relate specific echocardiographic findings to acute pericarditis. We hypothesized that pericardial hyperechogenicity and a defined finding that we named "pericardial comets", in analogy to lung comets, may be associated with acute pericarditis.
Methods:
We retrospectively analysed the echocardiograms of patients aged <50 y/o with a confirmed pericarditis diagnosis and compared them with 2 prospectively healthy controls groups (either < or > 50 y/o) to detect a potential association of pericardial hyperechogenicity and/or pericardial comets with acute pericarditis.
Results:
Comparison between the pericarditis and the control groups did not evidence significant differences regarding the prevalence of hyperechogenicity and pericardial comets when comparing patients with pericarditis and age-matched controls (younger than 50 years); the group of elderly healthy controls (>50 y/o) showed significantly lower prevalence of pericardial hyperechogenicity (p<0.001) and comets (p<0.001), compared with the other 2 groups. A significantly higher number of patients with pericarditis demonstrated ≥2 pericardial comets compared with age-matched controls (68% vs 48%, p=0.042).
Conclusion:
The echocardiographic prevalence of both pericardial hyperechogenicity and comets per patient is heavily influenced by age (inversely proportional), but the presence of at least 2 pericardial comets is significantly more frequent in patients with pericarditis than in healthy aged-matched controls. Nonetheless, this echocardiographic finding may have limited clinical usefulness, due to the frequent detection of ≥2 comets in healthy young subjects also.
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