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Prevalence of Endocrinopathies in Turkish Children With β-Thalassemia Major: A Single-Center Study

Ayça Altincik1, Mehmet Akin

  • 1*Pediatric Enocrinology Unit, State Hospital of Denizli †Department of Pediatric Hematology, Faculty of Medicine, Pamukkale University, Denizli, Turkey.

Journal of Pediatric Hematology/Oncology
|May 11, 2016
PubMed

Insights

Endocrine issues like vitamin D insufficiency and short stature are common in children with beta-thalassemia major (BTM), despite effective chelation. Regular monitoring of growth and endocrine function is crucial for improving quality of life in these patients.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Hematology

Background:

  • Chelation therapy has improved survival for patients with beta-thalassemia major (BTM).
  • Endocrine complications remain a significant challenge for BTM patients.
  • Understanding the prevalence and risk factors for endocrine issues is vital.

Purpose of the Study:

  • To determine the prevalence of endocrine complications in children with BTM.
  • To investigate the relationship between serum ferritin levels and these complications.

Main Methods:

  • Forty-five children with BTM (mean age 12.39 years) were enrolled.
  • Serum ferritin levels were measured.
  • Prevalence of endocrine complications including vitamin D insufficiency, short stature, pubertal impairment, and osteopenia was assessed.

Main Results:

  • The most common endocrine complications were vitamin D insufficiency (54.5%), short stature (42%), and pubertal impairment (25%).
  • Osteopenia was observed in 13% of patients.
  • Serum ferritin levels did not correlate with anthropometric or laboratory data.

Conclusions:

  • Endocrine complications are highly prevalent in children with BTM.
  • Monitoring growth, vitamin D status, and endocrine functions is essential for optimizing quality of life.
  • Further research may be needed to understand the specific mechanisms linking BTM and endocrine dysfunction.

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