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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
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Tumor microenvironment-specific nanoparticles activatable by stepwise transformation.

Hyewon Ko1, Soyoung Son1, Jueun Jeon2

  • 1Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon 440-746, Republic of Korea.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|May 11, 2016
PubMed
Summary
This summary is machine-generated.

Researchers developed novel tumor microenvironment-specific nanoparticles. These nanoparticles enhance drug delivery and antitumor efficacy by sequentially activating in response to tumor extracellular and intracellular conditions.

Keywords:
BiostabilityDrug deliveryStepwise transformationTumor microenvironment

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Drug Delivery

Background:

  • Developing effective tumor-targeted nanocarriers faces challenges in vivo.
  • Sequential activation strategies are needed for precise drug delivery within tumors.

Purpose of the Study:

  • To create tumor microenvironment-specific nanoparticles for enhanced in vivo drug delivery.
  • To overcome challenges associated with current nanocarrier applications.

Main Methods:

  • Synthesized polymeric nanoparticles using a pH-responsive, charge-convertible polyethyleneimine derivative.
  • Incorporated a reduction-responsive crosslink (disulfide bond) for intracellular drug release.
  • Evaluated nanoparticle behavior in response to tumor extracellular and intracellular environments.

Main Results:

  • Nanoparticles exhibited charge conversion from negative to positive in mildly acidic tumor extracellular matrix, enhancing cellular uptake.
  • Disulfide bonds in the nanoparticle core were cleaved in the intracellular reductive environment, enabling selective drug release.
  • Demonstrated high tumor targetability and significantly improved antitumor efficacy of the encapsulated drug.

Conclusions:

  • The developed tumor microenvironment-specific nanoparticles offer a promising platform for targeted cancer therapy.
  • Sequential activation strategies enhance nanocarrier performance for improved in vivo applications.
  • This approach dramatically improves antitumor efficacy by optimizing drug delivery to tumor tissues.