Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

28.5K
Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
28.5K
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

6.1K
Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
6.1K
Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

4.0K
4.0K
iPS Cell Differentiation01:22

iPS Cell Differentiation

3.3K
The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
3.3K
Stem Cell Culture01:17

Stem Cell Culture

6.5K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
6.5K
EPS and iPS Cells in Disease Research01:21

EPS and iPS Cells in Disease Research

3.5K
Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Validation of a Rule-Based Automated Method for RPE Cell Detection Using Adaptive Optics Transscleral Flood Illumination.

Translational vision science & technology·2026
Same author

RPE Abnormality Is a Potential Primary Cause for Retinal Degeneration in Mucopolysaccharidosis Type VI Patients and a Rat Model.

Investigative ophthalmology & visual science·2026
Same author

Genomic characterization of sub-populations in human pluripotent stem cell-derived retinal progenitor cells driving retinal lamination.

Stem cell reports·2026
Same author

Deep phenotyping of eyes shut homolog-associated retinopathy based on visual impairment patterns.

Frontiers in ophthalmology·2025
Same author

Hidden Markov models reveal behavioral state dynamics in depth-related locomotion in mice.

PloS one·2025
Same author

Therapeutic potential of allogeneic iPS cell-derived RPE transplantation for <i>RPE6</i>5-LCA.

American journal of ophthalmology case reports·2025

Related Experiment Video

Updated: Mar 21, 2026

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells
06:38

Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells

Published on: April 21, 2021

3.5K

[Retinal Cell Therapy Using iPS Cells].

Masayo Takahashi

    Nippon Ganka Gakkai Zasshi
    |May 12, 2016
    PubMed
    Summary

    Induced pluripotent stem (iPS) cell-derived retinal pigment epithelial (RPE) cell sheets show promise for treating age-related macular degeneration (AMD). Clinical research confirms the safety of this regenerative medicine approach for AMD patients.

    Area of Science:

    • Regenerative Medicine
    • Stem Cell Biology
    • Ophthalmology

    Context:

    • Advances in stem cell research, from neural stem cells to induced pluripotent stem (iPS) cells, are paving the way for regenerative medicine.
    • Age-related macular degeneration (AMD) is a leading cause of vision loss, often associated with cellular senescence of retinal pigment epithelial (RPE) cells.
    • Current treatments for AMD are limited, highlighting the need for innovative therapeutic strategies.

    Purpose:

    • To evaluate the safety and efficacy of transplanting iPS cell-derived RPE cell sheets for treating exudative age-related macular degeneration (AMD).
    • To explore the potential of regenerative medicine as a future treatment modality for various organ regeneration, including the central nervous system.
    • To investigate strategies for making regenerative medicine a standard treatment, considering factors like cost, benefit, and cell sourcing (autologous vs. allogeneic).

    More Related Videos

    Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
    10:05

    Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

    Published on: April 12, 2021

    7.0K
    Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
    09:47

    Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

    Published on: December 9, 2022

    4.7K

    Related Experiment Videos

    Last Updated: Mar 21, 2026

    Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells
    06:38

    Directed Induction of Retinal Organoids from Human Pluripotent Stem Cells

    Published on: April 21, 2021

    3.5K
    Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells
    10:05

    Retinal Organoid Induction System for Derivation of 3D Retinal Tissues from Human Pluripotent Stem Cells

    Published on: April 12, 2021

    7.0K
    Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells
    09:47

    Generation of Retinal Organoids from Healthy and Retinal Disease-Specific Human-Induced Pluripotent Stem Cells

    Published on: December 9, 2022

    4.7K

    Summary:

    • A clinical study transplanted iPS cell-derived RPE cell sheets into an AMD patient, marking the first clinical use of iPS cell-derived cells.
    • Safety was assessed one year post-surgery, with preclinical tests confirming cell sheet safety, purity, and genetic stability.
    • Future directions include exploring HLA-matched allogeneic transplantation and photoreceptor transplantation for neural network reconstruction in the central nervous system.

    Impact:

    • This research represents a significant step towards cell-based therapies for AMD and other degenerative diseases.
    • Successful RPE cell sheet transplantation could offer a radical new treatment for AMD by replacing senescent cells with healthy, young cells.
    • The study lays the groundwork for broader applications of regenerative medicine in treating conditions affecting the central nervous system and other organs.