Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Advances in methods for characterization of hepatic urea cycle enzymatic activity in HepaRG cells using UPLC-MS/MS.

Analytical biochemistry·2017

Same author

Liver Cell Culture Devices.

Cell medicine·2016

Same author

Pivotal preclinical trial of the spheroid reservoir bioartificial liver.

Journal of hepatology·2015

Same author

Systematic review: acute liver failure - one disease, more than 40 definitions.

Alimentary pharmacology & therapeutics·2012

Same author

[Recent developments in the treatment of chronic hepatitis B and C].

Nederlands tijdschrift voor tandheelkunde·2007

Same author

In vitro comparison of two bioartificial liver support systems: MELS CellModule and AMC-BAL.

The International journal of artificial organs·2007

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Published on: February 9, 2024

[(Bio)artificial liver support: ready for the patient?].

R A F M Chamuleau

Nederlands Tijdschrift Voor Tandheelkunde

|May 12, 2016

Summary

Artificial livers offer promising support for patients with liver failure, with bio-artificial liver technology showing the greatest potential for extending life expectancy. Clinical studies are encouraging but not yet sufficient for widespread use.

Area of Science:

Biomedical Engineering
Hepatology
Intensive Care Medicine

Background:

Artificial organs like artificial kidneys and heart-lung machines support patients with organ failure.
Severe liver failure necessitates liver transplantation for survival.
Current artificial liver technologies include devices for toxic material removal (e.g., albumin dialysis) and bio-reactors with liver cells (bio-artificial liver).

Purpose of the Study:

To review the development and potential of artificial livers for patients with severe liver failure.
To highlight the promise of bio-artificial liver technology in increasing patient life expectancy.

Main Methods:

Review of existing artificial liver technologies.
Analysis of clinical study outcomes for artificial livers, particularly bio-artificial liver systems.

More Related Videos

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

Related Experiment Videos

Last Updated: Mar 21, 2026

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Author Spotlight: Utilization of Decellularized Spleen Matrix for Bioartificial Livers

Published on: February 9, 2024

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Functional Human Liver Preservation and Recovery by Means of Subnormothermic Machine Perfusion

Published on: April 27, 2015

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Heterotopic Auxiliary Rat Liver Transplantation With Flow-regulated Portal Vein Arterialization in Acute Hepatic Failure

Published on: September 13, 2014

Main Results:

Bio-artificial liver technology theoretically offers the greatest potential for improving life expectancy in liver failure patients.
Clinical study results for artificial livers are very promising.

Conclusions:

Artificial livers, especially bio-artificial liver systems, represent a significant advancement in managing liver failure.
Further clinical data is required before bio-artificial liver technology can be widely adopted in clinical practice.