Related Experiment Video
Updated: Mar 21, 2026

In vitro Reconstitution of the Active T. castaneum Telomerase
Published on: July 14, 2011
Efficient Inhibition of Telomerase by Nickel-Salophen Complexes
Laureline Lecarme1, Enora Prado1, Aurore De Rache2
1Université Grenoble Alpes, Département de Chimie Moléculaire, UMR-5250, 38041, Grenoble Cedex 9, France.
Abstract:
Four nickel(II)-salophen complexes containing alkyl-imidazolium chains connected at the ortho or meta positions were prepared: N,N'-bis(2-hydroxy-4-methyl-3H-imidazol-1-iumbenzylideneamino)phenylenediamine (1), N,N'-bis(2-hydroxy-3-methyl-3H-imidazol-1-iumbenzylideneamino)phenylenediamine (2), N,N'-bis(2-hydroxy-3-methyl-3H-imidazol-1-iumbenzylideneamino)methyl-3H-imidazol-1-iumphenylenediamine (3), and N,N'-bis(2-hydroxy-4-methyl-3H-imidazol-1-iumbenzylideneamino)methyl-3H-imidazol-1-iumphenylenediamine (4). They protect G-quadruplex DNA (G4 -DNA) against thermal denaturation and show KA values in the range of 7.4×10(5) to 4×10(7) m(-1) for G4 -DNA models. Complex 4 exhibits an IC50 value of 70 nm for telomerase inhibition.
More Related Videos
Related Concept Videos
Telomeres and Telomerase
Replicative Cell Senescence
The Electron Transport Chain
Inhibitors of the electron transport chain
Rotenone, a widely used pesticide, prevents electron transfer from Fe-S cluster to ubiquinone or Q...
Enzyme Inhibition

