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Related Experiment Video

Updated: Mar 21, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Secondary Progressive Multiple Sclerosis: Definition and Measurement.

Domenico Plantone¹, Floriana De Angelis², Anisha Doshi²

¹Department of Neuroinflammation, Queen Square Multiple Sclerosis Centre, UCL Institute of Neurology, University College London, London, WC1N 3BG, UK. d.plantone@ucl.ac.uk.

|May 12, 2016

Summary

This summary is machine-generated.

Secondary progressive multiple sclerosis (SPMS) is a disabling neurological condition. Current treatments for SPMS show limited success due to a poor understanding of its progression and effective outcome measures.

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Area of Science:

Neurology
Neuroimmunology
Clinical Trials

Background:

Secondary progressive multiple sclerosis (SPMS) is characterized by progressive neurological disability.
SPMS diagnosis is retrospective, occurring after an initial relapsing-remitting (RR) phase.
Current understanding of neurodegeneration in MS is incomplete, hindering SPMS diagnosis and treatment.

Purpose of the Study:

To discuss the definition and variability of SPMS.
To review current and emerging outcome measurements for SPMS.
To explore modern clinical trial designs for SPMS.

Main Methods:

Literature review and synthesis of existing research on SPMS.
Analysis of diagnostic criteria and clinical progression in MS.
Evaluation of outcome measures and trial methodologies in SPMS studies.

Main Results:

SPMS definitions can vary, impacting clinical trials.
A lack of definitive diagnostic markers for SPMS progression exists.
Clinical trials for SPMS using immunosuppressants have yielded limited success.

Conclusions:

Improved understanding of SPMS pathology is crucial.
Development of reliable diagnostic tools for SPMS progression is needed.
Innovative clinical trial designs and outcome measures are essential for advancing SPMS therapeutics.