Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Mar 21, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

Killing me softly: microparticles target deformable cells.

Jens Hamann¹, Michael Overholtzer¹

¹Cell Biology Program and Louis V Gerstner Jr Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

|May 12, 2016

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Reprogramming of TLR-Ferroptosis Signaling and Immunometabolic Pathways Overcomes Myeloid Suppression to Improve Checkpoint Blockade in Prostate Cancer.

Cancer research·2026

Same author

Ferroptosis induces heterogeneous death profiles that are controlled by lysosome rupture.

Developmental cell·2026

Same author

An ultrasmall core-shell silica nanoparticle improves antitumour immunity and survival by remodelling suppressive melanoma microenvironments.

Nature nanotechnology·2025

Same author

Entosis in Health and Disease.

Advances in experimental medicine and biology·2025

Same author

ATG16L strikes again! New findings link lysosome stress and physiology.

The Journal of cell biology·2025

Same author

WNK1 mediates M-CSF-induced macropinocytosis to enforce macrophage lineage fidelity.

Nature communications·2025

Same journal

Why microglial repair programs fade.

Cell research·2026

Same journal

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.

Cell research·2026

Same journal

One drug, five targets.

Cell research·2026

Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026

Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026

Same journal

MitoCatch directs mitochondria delivery and prevents cell degeneration.

Cell research·2026

See all related articles

Cancer cells become more deformable as tumors grow. A new study reveals a microparticle drug delivery method targeting these deformable cancer cells for therapy.

Area of Science:

Biomedical Engineering
Cancer Biology
Drug Delivery Systems

Background:

Mechanical deformability is a hallmark of cancer progression.
Increased cell deformability correlates with tumor aggressiveness and metastatic potential.

Purpose of the Study:

To investigate the link between cancer progression and cell mechanical properties.
To develop and evaluate a novel therapeutic strategy targeting mechanically deformable cancer cells.

Main Methods:

Utilized microparticle-based drug delivery systems.
Characterized the mechanical properties of cancer cells at different stages of progression.
Assessed the efficacy of microparticle drug delivery in targeting deformable cells.

Main Results:

More Related Videos

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Related Experiment Videos

Last Updated: Mar 21, 2026

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Cell Squeezing as a Robust, Microfluidic Intracellular Delivery Platform

Published on: November 7, 2013

A Microfluidic Technique to Probe Cell Deformability

A Microfluidic Technique to Probe Cell Deformability

Published on: September 3, 2014

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Microfluidic Buffer Exchange for Interference-free Micro/Nanoparticle Cell Engineering

Published on: July 10, 2016

Confirmed that cancer cells exhibit increased mechanical deformability during tumor progression.
Demonstrated that microparticle-based drug delivery selectively targets and delivers therapeutic agents to these deformable cancer cells.
Showcased the potential of this approach to enhance cancer treatment efficacy.

Conclusions:

Targeting mechanical deformability represents a promising therapeutic avenue for cancer treatment.
Microparticle drug delivery offers a viable strategy for selectively delivering drugs to aggressive cancer cells.
Further research into mechanobiology-based cancer therapies is warranted.