Nutritional limitation in early postnatal life and its effect on aging and longevity in rodents

Nutrient limitation in the form of chronic dietary restriction (DR), or more specifically a life-long reduction of total daily nutritional intake, was first shown to extend longevity in rats more than eight decades ago and is one of the most robust anti-aging interventions known. More recently, it has become apparent that dietary restriction limited to only the first few weeks of life in rodents is also capable of significantly impacting aging and longevity. The imposition of nutrient limitation is often achieved via the manipulation of litter size or the modulation of maternal nutrient intake during the lactational period. Not surprisingly, nutrient limited pups are smaller at weaning, and remain so throughout their life, while exhibiting signs of slowed aging. In this review, we discuss potential mechanisms that account for the anti-aging effects of postnatal undernutrition with an emphasis on those pathways that parallel changes seen with chronic DR.