Pharmaceutical crystallization with nanocellulose organogels.

Area of Science:

• Materials Science
• Chemical Engineering
• Pharmaceutical Science

Background:

• Nanocellulose is a promising biomaterial with tunable properties.
• Organogels are gel-like materials formed from organic liquids.
• Controlling pharmaceutical solid forms is crucial for drug efficacy and stability.

Purpose of the Study:

• To investigate the formation of organogels using carboxylated nanocellulose and cationic surfactants.
• To explore the utility of these organogels as crystallization media for pharmaceutical compounds.
• To demonstrate the capability of organogels in controlling pharmaceutical solid form, including solvate isolation and morphology modification.

Main Methods:

• Formation of organogels using carboxylated nanocellulose at 0.3 wt% with a cationic surfactant.
• Utilizing the organogels as a medium for pharmaceutical crystallization.
• Characterization of the resulting crystalline forms and morphologies.

Main Results:

• Successful formation of carboxylated nanocellulose-based organogels at low concentrations (0.3 wt%).
• Demonstrated use of organogels for pharmaceutical solid form control.
• Isolation of a novel sulfapyridine solvate.
• Achieved morphology modification and crystallization of an octadecylammonium salt of sulfamethoxazole.

Conclusions:

• Carboxylated nanocellulose-based organogels represent a novel class of materials for pharmaceutical crystallization.
• These organogels offer a versatile platform for controlling solid-state properties of active pharmaceutical ingredients.
• The findings open avenues for advanced pharmaceutical manufacturing and drug delivery systems.