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Updated: Mar 21, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Prenatal pharmacogenomics: a promising area for research
E H Dorfman1, E Y Cheng2,3, M F Hebert4
1Department of Biostatistics, University of Washington, Institute for Public Health Genetics, Seattle, WA, USA.
Abstract:
Clinical applications of prenatal genetic screening currently focus on detection of aneuploidy and other genetic diseases in the developing fetus. Growing evidence suggests that the fetal genome may also be informative about fetal exposures through contributions to placental transport as well as placental and fetal metabolism. Possible clinical applications of prenatal pharmacogenomic screening include prospective optimization of medication selection and dosage, as well as retrospective assessment of whether a fetus was previously exposed to significant risk. Newly available noninvasive methods of prenatal genetic screening mean that relevant fetal genotypes could be made available to obstetricians for use in management of a current pregnancy. This promising area for research merits more attention than it has thus far received.The Pharmacogenomics Journal advance online publication, 10 May 2016; doi:10.1038/tpj.2016.33.
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