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Published on: February 7, 2018
Discovery of biomarkers for oxidative stress based on cellular metabolomics
Ningli Wang1,2,3, Jianteng Wei2,3, Yewei Liu1
1a Institute of Nutrition and Food Hygiene, School of Public Health, Lanzhou University , Lanzhou , China ;
Abstract:
Oxidative stress has a close relationship with various pathologic physiology phenomena and the potential biomarkers of oxidative stress may provide evidence for clinical diagnosis or disease prevention. Metabolomics was employed to identify the potential biomarkers of oxidative stress. High-performance liquid chromatography-diode array detector, mass spectrometry and partial least squares discriminate analysis were used in this study. The 10, 15 and 13 metabolites were considered to discriminate the model group, vitamin E-treated group and l-glutathione-treated group, respectively. Some of them have been identified, namely, malic acid, vitamin C, reduced glutathione and tryptophan. Identification of other potential biomarkers should be conducted and their physiological significance also needs to be elaborated.
