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Updated: Mar 21, 2026

A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
Wound-Related Allergic/Irritant Contact Dermatitis
Afsaneh Alavi1, R Gary Sibbald, Barry Ladizinski
1Afsaneh Alavi, MD • Assistant Professor • Department of Medicine (Dermatology), University of Toronto • Toronto, Ontario, Canada R. Gary Sibbald, BSc, MD, DSc (Hons), MEd, FRCPC (Med)(Derm), FAAD, MAPWCA • Professor • Medicine and Public Health • Director • International Interprofessional Wound Care Course (IIWCC) & Masters of Science Community Health (Prevention and Wound Care) • Dalla Lana Faculty of Public Health • University of Toronto • Toronto, Ontario, Canada • Clinical Editor • Advances in Skin & Wound Care Barry Ladizinski, MD, MPH, MBA • Dermatology Resident • Division of Dermatology • John H. Stroger, Jr. Hospital of Cook County • Chicago, Illinois Ami Saraiya, MD • Research Fellow • Department of Dermatology, Tufts University • Boston, Massachusetts Kachiu C. Lee, MD • Assistant Professor • Department of Dermatology, Brown University • Providence, Rhode Island Sandy Skotnicki-Grant, MD • Assistant Professor • Department of Dermatology, University of Toronto • Toronto, Ontario, Canada Howard Maibach, MD • Professor • Department of Dermatology, University of California, San Francisco School of Medicine.
Contact dermatitis, a common issue in wound care, can be irritant or allergic. Identifying and avoiding common allergens in wound care products is crucial for prevention and treatment.
Area of Science:
- Dermatology
- Wound Care
- Allergy & Immunology
Background:
- Contact dermatitis is a frequent, often overlooked problem in wound care.
- This review focuses on prevention, recognition, and treatment strategies.
Purpose of the Study:
- To review literature on contact dermatitis in the context of wound care.
- To equip healthcare professionals to identify, diagnose, and manage contact dermatitis.
Main Methods:
- A PubMed literature review was conducted for English-language articles.
- Searched articles published between January 2000 and December 2015.
Main Results:
- Contact dermatitis is primarily irritant (80%) or allergic (20%).
- Fragrances, colophony, lanolin, and topical antibiotics are common allergens in wound care.
- Impaired skin barrier function increases sensitization risk in chronic wound patients.
Conclusions:
- Clinicians must recognize allergens in wound care products and the risk of sensitization.
- Complete ingredient labeling for medical devices and removal of common allergens from products are recommended.
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