[Changes in systemic hemodynamics and vascular resistance in unilaterally nephrectomized rats with vasorenal...

Cardiac output (CO), arterial pressure (AP), and total peripheral resistance of the vessels were studied in rats on the 1st, 5th, and 20th day after the onset of one-kidney vasorenal hypertension. The CO increased by 72% and the peripheral resistance reduced on the 1st day. In stable increase of AD the CO did not differ from the control level. In extracorporeal perfusion of the hindquarters of hypertensive rats in the indicated periods increased reactivity of the vessels to noradrenaline and resistance at maximal dilatation were revealed. These changes were encountered even before statistically significant increase in AP (5th day) and increased with the gradual development of hypertension.