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Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

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The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by...
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Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Adrenal Gland Disorders01:27

Adrenal Gland Disorders

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Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

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Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
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Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

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Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
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Related Experiment Video

Updated: Mar 21, 2026

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
07:12

Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging

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Primary Hyperparathyroidism Through an Ectopic Parathyroid Adenoma.

Constantin Grozavu, Daniel Pantile

    Chirurgia (Bucharest, Romania : 1990)
    |May 13, 2016
    PubMed
    Summary

    A rare case of primary hyperparathyroidism due to a mediastinal parathyroid adenoma was successfully treated with surgery. Early diagnosis through advanced imaging is crucial for managing this severe condition.

    Area of Science:

    • Endocrinology
    • Surgical Pathology
    • Medical Imaging

    Background:

    • Parathyroid glands regulate calcium via parathormone (PTH) production.
    • Hyperparathyroidism involves excessive PTH secretion, leading to calcium imbalances.
    • Ectopic parathyroid glands can occur outside the typical cervical location.

    Observation:

    • A 48-year-old woman presented with severe bone pain, headache, and dizziness.
    • Imaging revealed a hypermetabolic nodule in the anterior mediastinum.
    • Surgical exploration identified a parathyroid adenoma in the mediastinum.

    Findings:

    • The mediastinal parathyroid adenoma was successfully removed surgically.
    • The patient experienced a favorable outcome with no postoperative complications.

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    Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation
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  • Nuclear medicine imaging significantly enhances parathyroid adenoma detection rates (~90%).
  • Implications:

    • Preoperative localization of ectopic parathyroid glands is essential for surgical planning.
    • Prompt diagnosis and surgical intervention can lead to remission of severe hyperparathyroidism symptoms.
    • Multimodality imaging (ultrasound, CT, MRI, scintigraphy) is recommended for comprehensive diagnosis.